HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1908248Generated: October 28, 2026
Acetonitrile → (1R)-2-{[2-Cyclopropyl-6-(3,4-dichlorophenyl)pyrimidin-4-yl]amino}-1-phenylethanol
https://huagongshe.com/reaction/1908248
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Chloro-2-cyclopropyl-6-(3,4-dichloro-phenyl)-Pyrimidine | HCID 80952663 | — |
| Reactant | HCID 178515609 | HCID 178515609 | — |
| Product | (1R)-2-{[2-Cyclopropyl-6-(3,4-dichlorophenyl)pyrimidin-4-yl]amino}-1-phenylethanol | HCID 44205060 | 81% |
Reaction Steps
4-Chloro-2-cyclopropyl-6-(3,4-dichloro-phenyl)-Pyrimidine. To a suspension of 2-cyclopropyl-6-(3,4-dichloro-phenyl)-pyrimidin-4-ol (131 mg, 0.467 mmol) in acetonitrile was added POCl3 (0.13 mL, 1.42 mmol). The reaction mixture was heated at 80° C. for 105 min, cooled to rt, quenched with satd. aq. NaHCO3, and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated. The crude residue was purified (FCC) to give the title compound (113 mg, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598202B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-b617f4ecac064816ba54657d852b0717 |
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| Source note | uspto-grants-2013_12 |
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