2-(3-phenyl-1H-pyrazol-1-yl)pyridine-3-carboxylic acid → Ethyl 2-hydroxy-4-phenyl-3-(2-(3-phenyl-1H-pyrazol-1-yl)nicotinamido)-butanoate

HRID 1908266Notes

Reaction equation

HRID 1908266 reaction equation
[C:1]1([C:7]2[CH:11]=[CH:10][N:9]([C:12]3[N:20]=[CH:19][CH:18]=[CH:17][C:13]=3[C:14]([OH:16])=O)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[CH2:22]([O:24][C:25](=[O:37])[CH:26]([OH:36])[CH:27]([NH3+:35])[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:23]>>[OH:36][CH:26]([CH:27]([NH:35][C:14](=[O:16])[C:13]1[CH:17]=[CH:18][CH:19]=[N:20][C:12]=1[N:9]1[CH:10]=[CH:11][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8]1)[CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[C:25]([O:24][CH2:22][CH3:23])=[O:37]

Participants

3

Reactant 2

HCID 667199602-(3-phenyl-1H-pyrazol-1-yl)pyridine-3-carboxylic acidHCID 86644788HCID 86644788, compound

Product 1

HCID 67242051Ethyl 2-hydroxy-4-phenyl-3-(2-(3-phenyl-1H-pyrazol-1-yl)nicotinamido)-butanoate

Procedure

The reaction was carried out in analogy to reaction step 1.1 starting from 2-(3-phenyl-1H-pyrazol-1-yl)nicotinic acid and 4-ethoxy-3-hydroxy-4-oxo-1-phenylbutan-2-aminium chloride; ESI-MS [M+H]+=471.2.

Sources & evidence

ORD record
ord-afadc3ed95ae4b4c9a52942466ca53e1
Source dataset
uspto-grants-2013_12
Patent number
US08598211B2

Reaction notes

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