HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → N-(4-(Cyclopropylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-2-(4-fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2-(4-Fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinic acid | HCID 67239001 | — |
| Reactant | HCID 178479578 | HCID 178479578 | — |
| Solvent | Pentane | HCID 8003 | — |
| Product | N-(4-(Cyclopropylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-2-(4-fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinamide | HCID 67237783 | — |
Reaction Steps
The reaction was carried out in analogy to reaction step 1.1 by reacting 2-(4-fluoro-3-phenyl-1H-pyrazol-1-yl)nicotinic acid and 4-(cyclopropylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-a minium chloride. The obtained crude product was treated with a mixture of dichloromethane and n-pentane gave 148 mg of the desired product; ESI-MS [M+H]+: 500.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598211B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-855d7d2996374b7a9014197a94a0669f |
| Source note | uspto-grants-2013_12 |