Cyclopropylamine → HCID 67238142, compound

HRID 1908278Notes

Reaction equation

HRID 1908278 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH:15][C:16](=[O:34])[C:17]2[CH:22]=[CH:21][CH:20]=[N:19][C:18]=2[N:23]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[N:24]2)[CH:10]([OH:14])[C:11]([OH:13])=O)[CH:5]=[CH:6][CH:7]=1.[CH:35]1([NH2:38])[CH2:37][CH2:36]1>>[CH:35]1([NH:38][C:11](=[O:13])[CH:10]([OH:14])[CH:9]([NH:15][C:16](=[O:34])[C:17]2[CH:22]=[CH:21][CH:20]=[N:19][C:18]=2[N:23]2[CH:27]=[CH:26][C:25]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[N:24]2)[CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 67239118HCID 67239118, compound

Product 1

HCID 67238142HCID 67238142, compound

Procedure

The reaction was carried out in analogy to reaction step 1.3 by reacting 4-(3-fluorophenyl)-2-hydroxy-3-(2-(3-phenyl-1H-pyrazol-1-yl)nicotinamido)butanoic acid with cyclopropylamine; ESI-MS [M+H]+: 500.2.

Workup

  1. customThe reaction was carried out in analogy to reaction step 1.3

Sources & evidence

ORD record
ord-187df9ff4ac645298262607b4388f543
Source dataset
uspto-grants-2013_12
Patent number
US08598211B2

Reaction notes

Loading…