HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 67094751, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67094830 | HCID 67094830 | — |
| Product | HCID 67094751 | HCID 67094751 | — |
Reaction Steps
The reaction was carried out in analogy to reaction step 1.3 by reacting 3-((R)-1-(2-fluorobenzyl)-5-oxopyrrolidine-2-carboxamido)-2-hydroxy-4-phenylbutanoic acid with cyclopropanamine using HATU (1.2 equivalents) as coupling reagent and DIPEA (3 equivalents) as base. ESI-MS [M+H]+=454.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598211B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-0162741419e04b79a5aafdd0bd539667 |
| Source note | uspto-grants-2013_12 |