HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 2-Bromo-4-(tert-butyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-Tert-Butylaniline | HCID 69861 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Bromo-4-(tert-butyl)aniline | HCID 238591 | — |
Reaction Steps
To a solution of 4-tert-Butyl-phenylamine (447 g, 3.00 mol) in DMF (500 mL) was added dropwise NBS (531 g, 3.00 mol) in DMF (500 mL) at room temperature. Upon completion, the reaction mixture was diluted with water and extracted with EtOAc. The organic layer washed with water, brine, dried over Na2SO4 and concentrated. The crude product was directly used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598181B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-63900e68de8142938ee4348efbe85334 |
| Source note | uspto-grants-2013_12 |