HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 66920056, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium periodate | HCID 23667635 | — |
| Reactant | 4-{(S)-4-tert-Butoxycarbonyl-2-[(5-furan-2-yl-1-phenyl-1H-pyrazole-3-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester | HCID 66920077 | — |
| Catalyst | Ruthenium trichloride | HCID 61850 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 66920056 | HCID 66920056 | — |
Reaction Steps
To a vigorously stirred mixture of 320 mg of 4-{(S)-4-tert-Butoxycarbonyl-2-[(5-furan-2-yl-1-phenyl-1H-pyrazole-3-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester in 2 ml of tetrachloromethane, 2 ml of acetonitrile and 3 ml of water, 531 mg of sodium periodate and 1 mg of ruthenium(III)chloride was added at RT. After 1 h, 20 ml of toluene was added and the solvents were removed under reduced pressure. The crude product was used in the subsequent reaction. Yield: 314 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598179B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-eeb84e6471ea4c9883806b48210eef5c |
| Source note | uspto-grants-2013_12 |