HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-((S)-2-{[5-(1-Ethoxycarbonyl-cyclobutoxy)-1-phenyl-1H-pyrazole-3-carbonyl]-amino}-4-methoxycarbonyl-butyryl)-piperazine-1-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | (4S)-4-([5-[1-(ethoxycarbonyl)cyclobutoxy]-1-phenyl-1H-pyrazol-3-yl]formamido)-5-[4-(ethoxycarbonyl)piperazin-1-yl]-5-oxopentanoic acid | HCID 44126037 | — |
| Product | 4-((S)-2-{[5-(1-Ethoxycarbonyl-cyclobutoxy)-1-phenyl-1H-pyrazole-3-carbonyl]-amino}-4-methoxycarbonyl-butyryl)-piperazine-1-carboxylic acid ethyl ester | HCID 66920340 | — |
Reaction Steps
To 30 mg of 4-((S)-4-Carboxy-2-{[5-(1-ethoxycarbonyl-cyclobutoxy)-1-phenyl-1H-pyrazole-3-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester, 2 ml of methanolic hydrochloric acid was added at RT and stirred for 3 h. Then, 10 ml of toluene was added and the solvents were removed under reduced pressure and the product was lyophilized to yield a white solid. Yield: 25 mg MS (ES+): m/e=614.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598179B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b1401476805641dc835bcd6b535d8e96 |
| Source note | uspto-grants-2013_12 |