HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 1-tert-Butoxycarbonylamino-cyclobutanecarboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cyclobutanecarboxylic acid, 1-(((1,1-dimethylethoxy)carbonyl)amino)- | HCID 1512646 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-tert-Butoxycarbonylamino-cyclobutanecarboxylic acid benzyl ester | HCID 66919931 | — |
Reaction Steps
To a solution of 2.0 g N-Boc-1-aminocyclobutane carboxylic acid in 100 ml dichloromethane were added 2.1 g EDC, 1.4 g DMAP, 2.2 ml pyridine and 4.8 ml benzyl alcohol. After stirring for 16 h the mixture was diluted with dichloromethane and washed with 0.1 M HCl and saturated aqueous NaHCO3. The crude product obtained after evaporation of the solvent was purified by chromatography on silica using heptane/ethyl acetate 2/1 as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598179B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-017a97d8b54d4126a4269072619f4656 |
| Source note | uspto-grants-2013_12 |