HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Benzyl 1-aminocyclobutane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-tert-Butoxycarbonylamino-cyclobutanecarboxylic acid benzyl ester | HCID 66919931 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzyl 1-aminocyclobutane-1-carboxylate | HCID 22120948 | — |
Reaction Steps
To a solution of 2.2 g 1-tert-Butoxycarbonylamino-cyclobutanecarboxylic acid benzyl ester in 20 ml dichloromethane were added 8 ml TFA. After stirring for 4 h the mixture was concentrated and the residue codistilled with toluene. The free amine was obtained by treatment with (Polystyrylmethyl)trimethylammonium bicarbonate in MeCN. Yield: 1.7 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598179B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-a0445c18e0d641c2aeefe09ef12e21fc |
| Source note | uspto-grants-2013_12 |