HCID 25763842, compound → HCID 71201915, compound

HRID 1908676Notes

Reaction equation

HRID 1908676 reaction equation
C(O[C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH:13][C:14]([C@H:16]2[CH2:18][C@@H:17]2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:15])[CH3:12])=[CH:7][CH:6]=1)(C)C.[CH3:25]C1N=CC([C@@H](N)C)=CC=1>>[CH3:25][C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH:13][C:14]([C@H:16]2[CH2:18][C@@H:17]2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:15])[CH3:12])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 25763842HCID 25763842, compoundHCID 71201914HCID 71201914, compound

Product 1

HCID 71201915HCID 71201915, compound

Procedure

Prepared analogously to Compound 1 using IM46 and commercially available (S)-1-(6-methyl-pyridin-3-yl)-ethylamine (Supplier Netchem Inc., Catalog No 519526). Yield=0.27 g (21%). 1H NMR (600 MHz, DMSO) δ 8.61 (d, 1H), 8.37 (s, 1H), 7.57 (d, 1H), 7.26 (m, 2H), 7.16 (m, 2H), 7.09 (d, 2H), 4.92 (m, 1H), 2.41 (s, 3H), 2.19 (m, 1H), 1.91 (m, 1H), 1.36 (m, 4H), 1.20 (m, 1H). LC-MS (m/z) 281.2 (MH+), tR=0.86 min (method A).

Sources & evidence

ORD record
ord-952f8397f91b47be9f60a3b423df87ba
Source dataset
uspto-grants-2013_12
Patent number
US08598213B2

Reaction notes

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