HCID 71201916, compound → HCID 71201918, compound

HRID 1908677Notes

Reaction equation

HRID 1908677 reaction equation
C[C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]([NH:10][C:11]([C@H:13]2[CH2:15][C@@H:14]2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:12])[CH3:9])=[N:6][CH:7]=1.Cl.[NH2:23][C@H:24](C1C=CC(C#N)=NC=1)C>>[C:7]([C:2]1[N:23]=[CH:24][C:5]([C@@H:8]([NH:10][C:11]([C@H:13]2[CH2:15][C@@H:14]2[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:12])[CH3:9])=[CH:4][CH:3]=1)#[N:6]

Participants

3

Reactant 2

HCID 71201916HCID 71201916, compoundHCID 86675614HCID 86675614, compound

Product 1

HCID 71201918HCID 71201918, compound

Procedure

Prepared analogously to Compound 2 using IM46 and commercially available 5-((S)-1-amino-ethyl)-pyridine-2-carbonitrile hydrochloride (Supplier Netchem Inc., Catalog No 549493). Yield=0.104 g (20%). %). 1H NMR (600 MHz, DMSO) δ 8.76 (d, 1H), 8.71 (s, 1H), 8.02 (d, 1H), 7.94 (d, 1H), 7.29 (m, 2H), 7.19 (m, 1H), 7.12 (d, 2H), 5.03 (m, 1H), 2.21 (m, 1H), 1.92 (m, 1H), 1.40 (d, 3H), 1.37 (m, 1H), 1.23 (m, 1H). LC-MS (m/z) 292.0 (MH+), tR=1.31 min (method A).

Sources & evidence

ORD record
ord-4864fd8391f642b6b6209f855570bbe1
Source dataset
uspto-grants-2013_12
Patent number
US08598213B2

Reaction notes

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