1417656-47-3 → HCID 71201920, compound

HRID 1908678Notes

Reaction equation

HRID 1908678 reaction equation
CC1C=CC([C@@H](N[C:11]([C@H:13]2[CH2:15][C@@H:14]2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:12])C)=NC=1.Cl.[F:23][C:24]([F:35])([F:34])[C:25]1[N:30]=[CH:29][C:28]([C@@H:31]([NH2:33])[CH3:32])=[CH:27][CH:26]=1>>[F:35][C:24]([F:34])([F:23])[C:25]1[N:30]=[CH:29][C:28]([C@@H:31]([NH:33][C:11]([C@H:13]2[CH2:15][C@@H:14]2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:12])[CH3:32])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 711829561417656-47-3HCID 71201916HCID 71201916, compound

Product 1

HCID 71201920HCID 71201920, compound

Procedure

Prepared analogously to Compound 2 using IM46 and commercially available (S)-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamine hydrochloride. (Supplier Netchem Inc., Catalog No 517662). Yield=0.33 g (55%). %). 1H NMR (500 MHz, DMSO) δ 8.77 (d, 1H), 8.72 (s, 1H), 7.99 (d, 1H), 7.88 (d, 1H), 7.27 (m, 2H), 7.17 (m, 1H), 7.13 (d, 2H), 5.05 (m, 1H), 2.20 (m, 1H), 1.93 (m, 1H), 1.41 (d, 3H), 1.37 (m, 1H), 1.23 (m, 1H). LC-MS (m/z) 335.2 (MH+), tR=1.59 min (method A).

Sources & evidence

ORD record
ord-d6998c0924e347918a9bb84dabec494f
Source dataset
uspto-grants-2013_12
Patent number
US08598213B2

Reaction notes

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