HCID 71201914, compound → HCID 71487163, compound

HRID 1908680Notes

Reaction equation

HRID 1908680 reaction equation
C(O[C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH:13][C:14]([C@H:16]2[CH2:18][C@@H:17]2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:15])[CH3:12])=[CH:7][CH:6]=1)(C)C.[Cl:25]C1N=CC([C@@H](N)C)=CC=1>>[Cl:25][C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH:13][C:14]([C@H:16]2[CH2:18][C@@H:17]2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:15])[CH3:12])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 71201914HCID 71201914, compoundHCID 72210815HCID 72210815, compound

Product 1

HCID 71487163HCID 71487163, compound

Procedure

Prepared analogously to Compound 1 using IM46 and commercially available (S)-1-(6-Chloro-pyridin-3-yl)-ethylamine (Aurora building blocks catalogue nr A06.814.555). Yield=1.40 g (71%). 1H-NMR (500 MHz, DMSO) δ 8.68 (d, 1H), 8.36 (s, 1H), 7.78 (d, 1H), 7.48 (d, 1H), 7.28 (m, 2H), 7.18 (m, 1H), 7.11 (d, 2H), 4.99 (m, 1H), 2.20 (m, 1H), 1.92 (m, 1H), 1.37 (m, 4H), 1.20 (m, 1H). LC-MS (m/z) 301.2 and 303.1 (MH+), tR=0.67 min (method B).

Sources & evidence

ORD record
ord-ecf0cfb6e5bd46c0bb63d5eae05411fd
Source dataset
uspto-grants-2013_12
Patent number
US08598213B2

Reaction notes

Loading…