Cyclohexanone → HCID 69010660, compound

HRID 1908704Notes

Reaction equation

HRID 1908704 reaction equation
[C:1]1(=[O:7])[CH2:6][CH2:5][CH2:4][CH2:3]C1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[C:11]([OH:18])[CH:10]=1.OC1C=CC=CC=1C(=O)C.CN1CCC2(CC(N)C3C(=CC=CC=3)O2)CC1>>[F:8][C:9]1[CH:10]=[C:11]2[C:12]([C:15](=[O:17])[CH2:16][C:5]3([O:18]2)[CH2:4][CH2:3][O:7][CH2:1][CH2:6]3)=[CH:13][CH:14]=1

Participants

5

Reactant 4

HCID 7967CyclohexanoneHCID 83752'-HydroxyacetophenoneHCID 27373264'-Fluoro-2'-hydroxyacetophenoneHCID 496168270505-90-7

Product 1

HCID 69010660HCID 69010660, compound

Procedure

The title compound was prepared using the procedure as described in Example 1A, substituting tetrahydro-4H-pyran-4-one for cyclohexanone and 4′-fluoro-2′hydroxyacetophenone for 2′-hydroxyacetophenone. 1 NMR (300 MHz, DMSO-d6) δ ppm 7.80 (dd, J=8.81, 6.78 Hz, 1H), 6.87-7.01 (m, 2H), 3.62-3.74 (m, 4H), 2.86 (s, 2H), 1.73-1.86 (m, 4H). MS (DCI+) m/z 237 (M+H), 254 (M+NH4).

Sources & evidence

ORD record
ord-fbb7cc4b64064ab79af8e539e5b59817
Source dataset
uspto-grants-2013_12
Patent number
US08598220B2

Reaction notes

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