HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,6-Dimethylisonicotinic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl 2,6-dimethylisonicotinate | HCID 67027153 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2,6-Dimethylisonicotinic acid hydrochloride | HCID 53393431 | — |
Reaction Steps
A solution of 2,6-dimethylisonicotinic acid tert.-butyl ester (2.37 g, 11.44 mmol) in 5 N HCl in isopropanol (40 mL) is stirred at 80° C. for 3 h. The solvent is evaporated and the crude product is purified by MPLC on silica gel (heptane:EA gradient) to give 2,6-dimethylisonicotinic acid hydrochloride as a beige resin; 1H NMR (CD3OD): δ 8.16 (s, 2H), 2.84 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598208B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-53a182301d1b481dadce4cb9edebb3f5 |
| Source note | uspto-grants-2013_12 |