2-Propenyl-6-methylisonicotinic acid ethyl ester → 2-Propyl-6-methylisonicotinic acid ethyl ester

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Reaction Steps

2-propenyl-6-methylisonicotinic acid ethyl ester (2.25 g, 10.9 mmol) is dissolved in THF (100 mL), Pd/C (300 mg, 10% Pd) is added and the mixture is stirred under 1 atm H2 at rt for 15 h. The catalyst is filtered off and the filtrate is evaporated to give 2-propyl-6-methylisonicotinic acid ethyl ester (2.30 g) as a colourless oil; LC-MS: tR=0.65 min, [M+1]+=208.12.

Provenance & Evidence