反应详情

A solution of 2,6-dichloroisonicotinic acid (20.0 g, 104 mmol) in ethanol (250 mL) and H2SO4 (5 mL) is stirred at 80° C. for 28 h. The solvent is removed in vacuo and the residue is dissolved in EA, washed with sat. aq. NaHCO3 solution and water, dried over MgSO4, filtered and evaporated to give 2,6-dichloroisonicotinic acid ethyl ester (17.7 g) as a brownish solid; LC-MS: tR=1.31 min.

1. customThe solvent is removed in vacuo
2. dissolutionthe residue is dissolved in EA
3. washwashed with sat. aq. NaHCO3 solution and water
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated