Ethyl 6-chloronicotinate → 121343-77-9

HRID 1908761Notes

Reaction equation

HRID 1908761 reaction equation
C([C:5]1[C:6]([CH3:14])=[N:7][CH:8]=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])C(C)C.C(O[C:18](=O)[C:19]1C=CC(Cl)=N[CH:20]=1)C.C([Mg]Cl)C(C)C>>[CH2:14]([C:6]1[CH:5]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]=1)[CH:19]([CH3:20])[CH3:18]

Participants

4

Reactant 3

HCID 2799611Ethyl 6-chloronicotinateHCID 58418068HCID 58418068, compoundHCID 178418368HCID 178418368, compound

Product 1

HCID 19865917121343-77-9

Procedure

6-Isobutyl-nicotinic acid is prepared in analogy to 5-isobutyl-6-methyl-nicotinic acid from commercially available 6-chloronicotinic acid ethyl ester and isobutylmagnesium chloride; LC-MS: tR=0.52 min, [M+1]+=180.30.

Sources & evidence

ORD record
ord-bdcf53f41ae941c19f6315cbced6c9f7
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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