HCID 67026964, compound → HCID 58418015, compound

Participants

Reaction Steps

A solution of 5-isobutyl-6-methoxy-nicotinic acid methyl ester (260 mg, 1.17 mmol) in 25% aq. HCl (10 mL) is stirred at 60° C. for 6 h. The solvent is evaporated and the residue is dried under HV to give the title compound (230 mg) as a white solid; LC-MS: tR=0.95 min; [M+1]+=210.51; 1H NMR (D6-DMSO): δ 0.86 (d, J=6.5 Hz), 1.84-1.95 (m, 1H), 2.46 (d, J=7.0 Hz, 2H), 3.95 (s, 3H), 7.93 (d, J=2.3 Hz, 1H), 8.59 (d, J=2.3 Hz, 1H).

Provenance & Evidence