N-Methylisopropylamine → HCID 58418042, compound

HRID 1908791Notes

Reaction equation

HRID 1908791 reaction equation
[CH2:1]([N:3]([CH3:14])[C:4]1[C:12]([CH3:13])=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=1)[CH3:2].[CH:15](NC)(C)C>>[CH:1]([N:3]([CH3:14])[C:4]1[C:12]([CH3:13])=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=1)([CH3:15])[CH3:2]

Participants

3

Reactant 2

HCID 78485N-MethylisopropylamineHCID 58418024HCID 58418024, compound

Product 1

HCID 58418042HCID 58418042, compound

Procedure

The title compound is prepared in analogy to 6-(ethyl-methyl-amino)-5-methyl-nicotinic acid using N-isopropyl-methyl-amine; LC-MS: tR=0.58 min, [M+1]+=209.10; 1H NMR (D6-DMSO): δ 1.23 (d, J=6.5 Hz, 6H), 2.40 (s, 3H), 2.97 (s, 3H), 4.22 (hept, J=6.8 Hz, 1H), 8.07 (s, 1H), 8.43 (d, J=2.0 Hz, 1H).

Sources & evidence

ORD record
ord-4ec640d226cb4e2e9f3b6cca9d7b285b
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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