Potassium Permanganate → HCID 67027109, compound

HRID 1908809Notes

Reaction equation

HRID 1908809 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:9][OH:10])[CH:3]=1.[O-:11][Mn](=O)(=O)=O.[K+:16]>CC(C)=O>[K+:16].[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]([O-:11])=[O:10])[CH:3]=1

Participants

4

Reactant 2

HCID 516875Potassium PermanganateHCID 67027007(4-BROMO-6-METHYL-PYRIDIN-2-YL)-METHANOL

Product 1

HCID 67027109HCID 67027109, compoundYield 116%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of (4-bromo-6-methyl-pyridin-2-yl)-methanol (1.31 g, 6.48 mmol) in acetone (150 mL), KMnO4 (2.61 g, 16.5 mmol) is added. The mixture is stirred at 40° C. for 2 h before it is filtered over a sintered glass funnel. The filtrate is evaporated to dryness, the remaining solid is washed with water and dried under HV to give 4-bromo-6-methyl-pyridine-2-carboxylic acid potassium salt (1.91 g) as a white solid; LC-MS: tR=0.45 min, [M+1]+=217.89.

Workup

  1. filtrationis filtered over a sintered glass funnel
  2. customThe filtrate is evaporated to dryness
  3. washthe remaining solid is washed with water
  4. customdried under HV

Sources & evidence

ORD record
ord-b33b130f2686450eab5df7b6cf7d7ac1
Source dataset
uspto-grants-2013_12
Patent number
US08598208B2

Reaction notes

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