Ammonia → HCID 25002739, compound

HRID 1908932Notes

Reaction equation

[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]2[CH:10]3[O:20][CH:13]([CH2:14][C:15]=2[C:16]=1[C:17]([OH:19])=O)[CH2:12][CH2:11]3)=[O:5].[F:29][C:30]([F:35])([F:34])[CH2:31][CH2:32][NH2:33].N>>[F:1][C:2]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:26])([F:27])[F:28])[C:3]=1[C:4]([NH:6][C:7]1[S:8][C:9]2[CH:10]3[O:20][CH:13]([CH2:14][C:15]=2[C:16]=1[C:17]([NH:33][CH2:32][CH2:31][C:30]([F:35])([F:34])[F:29])=[O:19])[CH2:12][CH2:11]3)=[O:5]

Participants

Reactant 3

HCID 222Ammonia

HCID 100013,3,3-Trifluoropropylamine

HCID 668459064-(2-Fluoro-6-trifluoromethyl-benzoylamino)-11-oxa-3-thia-tricyclo[6.2.1.02,6]undeca-2(6),4-diene-5-carboxylic acid

Product 1

HCID 25002739HCID 25002739, compound

Procedure

The title compound was prepared from the product of Example 4A and commercially available 3,3,3-trifluoropropylamine according to the procedure described for Example 4B. MS (DCI/NH3) m/z 511 (M+H)+.

Sources & evidence

ORD record: ord-6bc699c5b26948a09ee6db46c01a31b0
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08598224B2

Reaction notes

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