Phosphorus oxychloride → HCID 86662380, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7,8-dimethoxy-3-(phenylsulfonyl)-[1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one (262 mg, 0.68 mmol) and tetrabutylammonium chloride (189 mg, 0.68 mmol) in POCl3 (10 mL) was heated at 120° C. for 30 min and then cooled to room temperature. After removal of POCl3 in vacuo, the residue was purified by column chromatography on silica gel eluting with 30% ethyl acetate in hexane to yield 5-chloro-7,8-dimethoxy-3-(phenylsulfonyl)-[1,2,3]triazolo[1,5-a]quinazoline (162 mg, 59%). 1H NMR (CDCl3, 600 MHz) δ 8.28-8.26 (m, 2H), 8.04 (s, 1H), 7.61 (s, 1H), 7.60-7.58 (m, 1H); 7.56-7.54 (m, 2H), 4.18 (s, 3H), 4.10 (s, 3H); MS (ES+) m/z 405.0 (M+H)+

Provenance & Evidence