Hydrochloric Acid → HCID 43144877, compound

Participants

Reaction Steps

Compound 1 (1.5 g, 7.6 mmol, 1.0 eq) was dissolved in ethanol (30 mL) and 1N NaOH (15 mL) was added. The mixture was refluxed for 18 h and after cooling the reaction was neutralized with 1N HCl (15 mL) and the reaction was concentrated in vacuo. The crude reaction was dissolved in 10% MeOH/CH2Cl2 and the undissolved salt was filtered off and the solvents were removed in vacuo to afford the title compound as a white solid: 1H NMR (400 MHz, DMSO-d6) δ 8.46 (d, J=2.7 Hz, 1H), 8.39-8.36 (m, 2H), 8.06 (ddd, J=8.7, 2.7, 1.1 Hz, 1H), 7.88 (dd, J=8.7, 5.4 Hz, 1H), 7.40 (d, J=2.2 Hz, 1H), 7.12 (dd, J=5.7, 2.4 Hz, 1H); ES-MS [M+1]+: 217.1.

Provenance & Evidence