1,2-Dichloroethane → HCID 178519372, compound

Participants

Reaction Steps

To a stirred solution of 1H-benzoimidazole-5-carboxylic acid (10 g, 61.7 mmol), morpholine (7.55 mL, 86.3 mmol), ethyldiisopropylamine (16.1 mL, 92.5 mmol) and 4-dimethylaminopyridine (380 mg, 3.08 mmol) in DMF (60 mL) at room temperature was added EDC (12.4 g, 64.8 mmol) in a single portion. The mixture was stirred at room temperature for 3 days then concentrated in vacuo. The product was purified by recrystallisation from acetonitrile (70 mL), providing (1H-benzoimidazol-5-yl)-morpholin-4-yl-methanone (8.7 g).

Provenance & Evidence