反应详情

温度

90 °C

A flask containing 2-bromo-N-methoxy-N-methyl-isonicotinamide (Example 25, using method 2) (3.0 g, 12.2 mmol) 2,3-difluoro-6-methoxyphenylboronic acid (4.6 g, 24.4 mmol)) and 2M aqueous K3PO4 (15 mL, 30.6 mmol) in 1,4-dioxane (40 mL) was successively evacuated and flushed with nitrogen. Pd(PtBu3)2 (268 mg, 0.48 mmol) was then added and the mixture heated at 90° C. for 2 hours. The mixture was cooled, concentrated in vacuo and then partitioned between EtOAc and sat. aqueous NaHCO3 solution. The organic layer was washed with brine, dried (MgSO4) and concentrated in vacuo. Purification by SiO2 chromatography (eluting with 30-100% EtOAc/hexane) gave the title compound (0.856 g, 23%). MS(ESI) m/z 309 (M+H)+

1. customwas successively evacuated
2. customflushed with nitrogen
3. temperatureThe mixture was cooled
4. concentrationconcentrated in vacuo
5. custompartitioned between EtOAc and sat. aqueous NaHCO3 solution
6. washThe organic layer was washed with brine
7. dry with materialdried (MgSO4)
8. concentrationconcentrated in vacuo
9. customPurification
10. washby SiO2 chromatography (eluting with 30-100% EtOAc/hexane)