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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1909019Generated: October 30, 2026

2-Methoxyphenylboronic acid → 6-Cyano-2'-methoxy-biphenyl-3-carboxylic acid methyl ester

https://huagongshe.com/reaction/1909019

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methoxyphenylboronic acidHCID 2733958—
ReactantMethyl 3-bromo-4-cyanobenzoateHCID 23379143—
Product6-Cyano-2'-methoxy-biphenyl-3-carboxylic acid methyl esterHCID 6728611374.8%

Reaction Steps

By following procedures described in General procedure C (Suzuki), 3-bromo-4-cyano-benzoic acid methylester (0.205 g, 0.85 mmol) and 2-methoxy phenyl boronic acid (0.156 g, 1.02 mmol) were used to obtain the title compound (0.170 g, 62%), following SiO2 chromatography (hexanes/EtOAc=6:1). MS(ESI) m/z 268.0 (M+H)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08598217B2
Source datasetuspto-grants-2013_12
ORD IDord-687d9a62e2b0439a98abbd5e406145e9
Source noteuspto-grants-2013_12