HCID 66599715, compound → HCID 66599747, compound

HRID 1909022Notes

Reaction equation

HRID 1909022 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:14]=[C:13]([CH:15]([C:17]2[N:18]([CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:35])([CH3:34])[CH3:33])[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH3:27])[CH:26]=3)=[CH:20][N:21]=2)[OH:16])[CH:12]=[CH:11][N:10]=1>ClCCl.[O-2].[O-2].[Mn+4]>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[C:9]1[CH:14]=[C:13]([C:15]([C:17]2[N:18]([CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:35])([CH3:34])[CH3:33])[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH3:27])[CH:26]=3)=[CH:20][N:21]=2)=[O:16])[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 1

HCID 66599715HCID 66599715, compound

Product 1

HCID 66599747HCID 66599747, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of [2-(2,6-difluoro-phenyl)-pyridin-4-yl]-[5-(1-methyl-1H-pyrazol-4-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]methanol (78 mg, 0.157 mmol, as a mixture of two regioisomers) in dichloromethane (3 mL) at room temperature was added manganese dioxide (273 mg, 3.14 mmol). The mixture was stirred at room temperature overnight before it was filtered and concentrated in vacuo. Purification by SiO2 chromatography provided [2-(2,6-difluoro-phenyl)-pyridin-4-yl]-[5-(1-methyl-1H-pyrazol-4-yl)-1-(2 trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone (75 mg, as a mixture of two regioisomers).

Workup

  1. filtrationwas filtered
  2. concentrationconcentrated in vacuo
  3. customPurification by SiO2 chromatography

Sources & evidence

ORD record
ord-9e50ed26ac754c6996e79146d5daecdb
Source dataset
uspto-grants-2013_12
Patent number
US08598217B2

Reaction notes

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