HCID 66599575, compound → HCID 66599611, compound

HRID 1909024Notes

Reaction equation

HRID 1909024 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:16][CH2:15][CH:14]([N:17]([CH3:19])[CH3:18])[CH2:13][CH2:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>CCO.[Pd]>[CH3:18][N:17]([CH3:19])[CH:14]1[CH2:13][CH2:12][N:11]([C:4]2[CH:3]=[C:2]([NH2:1])[C:7]([NH2:8])=[CH:6][CH:5]=2)[CH2:16][CH2:15]1

Participants

4

Reactant 1

HCID 66599575HCID 66599575, compound

Product 1

HCID 66599611HCID 66599611, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To [1-(3-amino-4-nitro-phenyl)piperidin-4-yl]-dimethyl-amine (3.8 g, 14.4 mmol) was added Pd/C (300 mg) in EtOH (205 mL). The flask was shaken under H2 atmosphere for 6 hours. The catalyst was removed by filtration and the filtrate evaporated to dryness to give 4-(4-dimethylamino-piperidin-1-yl)benzene-1,2-diamine which was used directly in the next step.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-e9c1f65f65a247119b7716a94ac0660f
Source dataset
uspto-grants-2013_12
Patent number
US08598217B2

Reaction notes

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