HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Bromo-1,6-naphthyridine → 4-Cyano-3-[1,6]naphthyridin-8-yl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Bromo-1,6-naphthyridine | HCID 817270 | — |
| Reactant | Methyl 4-cyano-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate | HCID 56973105 | — |
| Product | 4-Cyano-3-[1,6]naphthyridin-8-yl-benzoic acid methyl ester | HCID 66599680 | — |
Reaction Steps
Using, 8-bromo-[1,6]naphthyridine (1 mol. eq.) and 4-cyano-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester (2.0 mol. eq.) as starting materials, the product was prepared using General procedure L (Suzuki) to give the title compound. MS(ESI) m/z 290.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598217B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-664ccfe8b7964f98a1c8934625407d86 |
| Source note | uspto-grants-2013_12 |