Hydrochloric Acid → HCID 178519756, compound

Participants

Reaction Steps

The mixture of 4-[2-(2-Isoquinolin-4-yl-pyridine-4-carbonyl)-3H-imidazo[4.5-b]pyridine-5-yl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester (15 mg, 0.03 mmole) and 2 molar HCl in ether (1 ml) was stirred at room temperature for 2 hours. Solvent was removed. Residue was washed with ethyl ether a few times to afford (5-[1,4]diazepan-1-yl-3H-imidazo[4,5-b]pyridine-2-yl)-(2-isoquinolin-4-yl-pyridin-4-yl)-methanone (6 mg, 49%) as a yellow solid. 1H NMR (400 MHz, CD3OD) δ 2.26 (m, 2H), 3.34 (m, 2H), 3.48 (m, 2H), 3.89 (m, 2H), 4.15 (m, 2H), 7.16 (m, 1H), 7.95 (m, 1H), 8.20 (m, 3H), 8.41-9.16 (m, 5H), 9.93 (d, J=6.53 Hz, 1H). HR-MS m/z 450.2033 [M+1].

Provenance & Evidence