HCID 67285786, compound → HCID 66599421, compound

Participants

Reaction Steps

The mixture of [1-(6-amino-5-nitro-pyridin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (2 g, 2.17 mmole), Pd/C (148 mg, 1.23 mmole), and EtOH (100 ml) was shaken under H2 gas for 2 days. Reaction solution was filtered and filtrate was concentrated to afford [1-(5,6-diamino-pyridin-2-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (1.8 g, ˜100%) as a dark green solid. 1H NMR (400 MHz, CD3OD) δ 1.17 (m, 1H), 1.44 (s, 9H), 1.86 (m, 16H), 2.18 (m, 12H), 3.14 (m, 1H), 3.42 (m, 1H), 3.59 (m, 1H), 4.505 (m, 1H), 6.67 (d, J=6.53 Hz, 1H), 6.920 (m, 1H). MS(ESI) m/z 294 [M+1].

Provenance & Evidence