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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1909072Generated: October 29, 2026

Phosphorus oxychloride → Methyl 6-chloro-5-cyanopicolinate

https://huagongshe.com/reaction/1909072

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxychlorideHCID 24813—
ReactantHCID 178497943HCID 178497943—
SolventDimethylformamideHCID 6228—
ProductMethyl 6-chloro-5-cyanopicolinateHCID 53302036—

Reaction Steps

5-Cyano-6-hydroxy-pyridine-2-carboxylic acid methyl ester is treated with phosphorus oxychloride in dimethylformamide in accordance with known methods to give 6-chloro-5-cyano-pyridine-2-carboxylic acid methyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08598217B2
Source datasetuspto-grants-2013_12
ORD IDord-61467d57e1c643e9bcd19b1b7748e73d
Source noteuspto-grants-2013_12