HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,5-Trimethylpyrazole-4-boronic acid → 5-cyano-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-pyridine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,5-Trimethylpyrazole-4-boronic acid | HCID 11171100 | — |
| Reactant | Methyl 6-chloro-5-cyanopicolinate | HCID 53302036 | — |
| Product | 5-cyano-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-pyridine-2-carboxylic acid methyl ester | HCID 66599884 | — |
Reaction Steps
The title compound may be prepared from 6-chloro-5-cyano-pyridine-2-carboxylic acid methyl ester by reaction with 1,3,5-trimethylpyrazol-4-ylboronic acid under Suzuki reaction conditions as described in the previous examples.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598217B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-06d9ca30e6514c9f8d9b491fd4fbd682 |
| Source note | uspto-grants-2013_12 |