Hydrochloric Acid → 3-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]-piperidine

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Reaction Steps

To a solution of 3-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester (1.0 g, 2.8 mmol) in CH2Cl2 (11 mL) was added HCl (4 M in dioxane, 4.2 mL, 16.9 mmol). The reaction mixture was stirred at r.t. overnight and then concentrated to give 3-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]-piperidine as the hydrochloride salt (791 mg, 96%). The crude product was used without further purification.

Provenance & Evidence