HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Vortioxetine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Vortioxetine | HCID 9966051 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Vortioxetine hydrobromide | HCID 56843850 | 47% |
Reaction Steps
49.5 gram of 1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine colourless oil was dissolved in 500 mL ethyl acetate and added 18.5 mL 48%-wt HBr (aq). This addition caused formation of a thick slurry which was stirred over night at room temperature. Filtration and drying in vacuum (50° C.) over night produced the product in 29.6 gram as white solid (47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598348B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-9e2ee4c50fe342778d20e638180395d5 |
| Source note | uspto-grants-2013_12 |