HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Methyl-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}propane-2-sulfinamide | HCID 66661445 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethanamine | HCID 66661534 | 98.2% |
Reaction Steps
To a solution of 2-methyl-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}propane-2-sulfinamide (7.23 g, 24.5 mmol) in methanol (100 mL) was added HCl (4.0 M in dioxane; 18.5 mL, 74.0 mmol). The mixture was stirred at ambient temperature. After 1 h, the mixture was concentrated to give the title compound (4.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598209B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-bc9ab0f4c4cb4e45a8bdb4a6803a9a8a |
| Source note | uspto-grants-2013_12 |