Morpholine → HCID 67338283, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-chloro-6-(2-fluoro-4-methylphenyl)isonicotinate (0.26 g, 0.94 mmol) in DMA (4 mL) were added morpholine (0.10 mL, 1.17 mmol), tris(dibenzylideneacetone)dipalladium(0) (21.4 mg, 0.02 mmol), 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl (33.5 mg, 0.07 mmol) and cesium carbonate (0.46 g, 1.41 mmol). The mixture was heated to 80° C. After 18 h, the mixture was filtered. The filtered cake was washed with methanol. The filtrate was concentrated to remove methanol. The solution in DMA was carried onto the next step.

Provenance & Evidence