Potassium Phosphate, Tribasic → HCID 67337889, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2,6-dichloropyrimidine-4-carboxylate (0.39 g, 1.87 mmol) in DMF (15 mL) were added (4-methylphenyl)boronic acid (0.84 g, 6.17 mmol), potassium phosphate tribasic (0.79 g, 3.74 mmol) and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (0.15 g, 0.19 mmol). The mixture was heated to 80° C. After 16 h, the mixture was cooled to ambient temperature. Saturated aqueous sodium bicarbonate was added and the mixture was extracted with ethyl acetate (3×). The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated. Purification by silica gel chromatography (100% hexanes→70% hexanes/ethyl acetate) gave the title compound (0.31 g). MS 319.2 (M+1).

Provenance & Evidence