HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(aminomethyl)-4-(methoxymethyl)-6-methyl-2(1H)-Pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Methyl-4-methoxymethyl-5-cyano-6-oxypyridine | HCID 94999 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(aminomethyl)-4-(methoxymethyl)-6-methyl-2(1H)-Pyridinone | HCID 55255763 | 80% |
Reaction Steps
To a solution of 4-(methoxymethyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (0.165 g, 0.927 mmol) in methanol (10 mL), Raney Ni and ammonia (1 mL) were added and reaction stirred under hydrogen balloon pressure for 3 h. On completion, reaction mass was filtered through celite bed and filtrate concentrated to obtain the desired compound (0.13 g, 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598167B1 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-fd4e7366a358403e91456834f2c3e5d2 |
| Source note | uspto-grants-2013_12 |