HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(aminomethyl)-4-ethyl-6-methylpyridin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 178436607 | HCID 178436607 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(aminomethyl)-4-ethyl-6-methylpyridin-2(1H)-one | HCID 67466583 | 87.9% |
Reaction Steps
To a solution of 4-ethyl-2-hydroxy-6-methylnicotinonitrile (0.5 g, 3.08 mmol) in methanol (10 mL), Raney Ni and ammonia (1 mL) were added and reaction stirred under hydrogen balloon pressure for 3 h. On completion, reaction mass was filtered through celite bed and filtrate concentrated to obtain the desired product (0.45 g, 87.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598167B1 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-18601161edb841a793bec7ed9d53843a |
| Source note | uspto-grants-2013_12 |