2-(1,4-Dioxan-2-yl)acetic acid → HCID 178520370, compound

Participants

Reaction Steps

The title compound, white solid (28.4 mg, 45.4%), MS (ISP) m/z=459.5 [(M+H)+], was prepared in accordance with the general method of example 1 Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (50 mg, 0.136 mmol) and rac-(1,4-dioxan-2-yl)-acetic acid obtained from saponification of the racemic [1,4]Dioxan-2-yl-acetic acid ethyl ester prepared as reported in Tetrahedron Vol. 45, 1989, pp. 69-76.

Provenance & Evidence