Methyl (oxetan-3-yl)acetate → HCID 178520365, compound

HRID 1909386Notes

Reaction equation

HRID 1909386 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[O:26]1[CH2:29][CH:28]([CH2:30][C:31](OC)=[O:32])[CH2:27]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:31](=[O:32])[CH2:30][CH:28]5[CH2:29][O:26][CH2:27]5)[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 55296082Methyl (oxetan-3-yl)acetateHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178520365HCID 178520365, compound

Procedure

The title compound, white solid (22.9 mg, 76.3%), MS (ISP) m/z=429.5 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (25.7 mg, 0.070 mmol) and methyl 2-(oxetan-3-yl)acetate.

Sources & evidence

ORD record
ord-aa3c316a3ee245d7a635089cb69dd30f
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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