HCID 66653522, compound → HCID 178496550, compound

HRID 1909387Notes

Reaction equation

HRID 1909387 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[CH3:26][O:27][C@@H:28]1[CH2:32][CH2:31][C@@H:30]([CH2:33][C:34](OC)=[O:35])[CH2:29]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:34](=[O:35])[CH2:33][C@@H:30]5[CH2:31][CH2:32][C@@H:28]([O:27][CH3:26])[CH2:29]5)[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 66653522HCID 66653522, compoundHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178496550HCID 178496550, compound

Procedure

The title compound, white solid (22.2 mg, 77.4%), MS (ISP) m/z=471.5 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (25.7 mg, 0.070 mmol) and methyl 2-((1R,3R)-3-methoxycyclopentyl)acetate.

Sources & evidence

ORD record
ord-f4d7d7e39c3a470cb139e63278bf8380
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

Loading…