(+-)-Tetrahydro-2-furoic acid → HCID 178523616, compound

HRID 1909401Notes

Reaction equation

HRID 1909401 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[O:26]1[CH2:30][CH2:29][CH2:28][CH:27]1[C:31](O)=[O:32]>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:31]([CH:27]5[CH2:28][CH2:29][CH2:30][O:26]5)=[O:32])[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 86079(+-)-Tetrahydro-2-furoic acidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178523616HCID 178523616, compound

Procedure

The title compound, white solid (17.6 mg, 60.3%), MS (ISP) m/z=429.2 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (25 mg, 0.0681 mmol) and tetrahydrofuran-2-carboxylic acid

Sources & evidence

ORD record
ord-3e614b8fd4054c0886805f5946a5bfce
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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