Oxane-4-carboxylic acid → HCID 178523619, compound

HRID 1909403Notes

Reaction equation

HRID 1909403 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[O:26]1[CH2:31][CH2:30][CH:29]([C:32](O)=[O:33])[CH2:28][CH2:27]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:32]([CH:29]5[CH2:30][CH2:31][O:26][CH2:27][CH2:28]5)=[O:33])[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 219302Oxane-4-carboxylic acidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178523619HCID 178523619, compound

Procedure

The title compound, white solid (22.3 mg, 74%), MS (ISP) m/z=443.3 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (25 mg, 0.0681 mmol) and tetrahydro-2H-pyran-4-carboxylic acid.

Sources & evidence

ORD record
ord-e11c9cbf77a44985b155d52177fc36dc
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

Loading…