4-(Morpholin-4-yl)benzoic acid → HCID 178523615, compound

HRID 1909411Notes

Reaction equation

HRID 1909411 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[O:26]1[CH2:31][CH2:30][N:29]([C:32]2[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=2)[CH2:28][CH2:27]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:36](=[O:37])[C:35]5[CH:34]=[CH:33][C:32]([N:29]6[CH2:30][CH2:31][O:26][CH2:27][CH2:28]6)=[CH:40][CH:39]=5)[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 3452784-(Morpholin-4-yl)benzoic acidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178523615HCID 178523615, compound

Procedure

The title compound, white solid (31.1 mg, 73.2%), MS (ISP) m/z=520.3 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (30 mg, 0.0818 mmol) and 4-morpholinobenzoic acid.

Sources & evidence

ORD record
ord-d718637b47ca40ecba60dd22e3e7a192
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

Loading…