4-Quinolinecarboxylic acid → HCID 178523617, compound

HRID 1909412Notes

Reaction equation

HRID 1909412 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[N:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:29]([C:36](O)=[O:37])=[CH:28][CH:27]=1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:36]([C:29]5[C:30]6[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=6)[N:26]=[CH:27][CH:28]=5)=[O:37])[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 102434-Quinolinecarboxylic acidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178523617HCID 178523617, compound

Procedure

The title compound, white solid (29.6 mg, 74.6%), MS (ISP) m/z=486.3 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (30 mg, 0.0818 mmol) and quinoline-4-carboxylic acid.

Sources & evidence

ORD record
ord-d96f5478afff4748b507fcdb8aa54896
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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