Chroman-3-carboxylic acid → HCID 178523622, compound

HRID 1909415Notes

Reaction equation

HRID 1909415 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[O:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH:28]([C:36](O)=[O:37])[CH2:27]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:36]([CH:28]5[CH2:29][C:30]6[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=6)[O:26][CH2:27]5)=[O:37])[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 2795458Chroman-3-carboxylic acidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178523622HCID 178523622, compound

Procedure

The title compound, white solid (28.5 mg, 71%), MS (ISP) m/z=491.4 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (30 mg, 0.0818 mmol) and chroman-3-carboxylic acid.

Sources & evidence

ORD record
ord-2707a743834e4aec8c12b6bfdf98e14c
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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